Authors :

A. Brindha Devi* and A. Durga Devi**,

Author Address :

*Department of Bioinformatics, Marudupandiyar College, Thanjavur, Tamilnadu, India. **Department of Physics, Bharathidasan University, Trichy, Tamilnadu, India

Abstract :

Influenza is an acute respiratory tract infection caused by the influenza virus, of which there are 3 types A, B and C. Influenza spreads around the world as seasonal epidemics resulting in the deaths of hundreds of thousands annually. All known pandemics were caused by influenza A strains. Antiviral medicines like amantaidne, rimantadine, oseltamivir and zanamivir are highly recommended in controlling the infection. These drugs are considered as ligands which bind with the receptor proteins neuroaminidase and m2 of influenza virus. The present study was initiated with an objective to elucidate the interaction potential of all the above ligands. From the results it is evident that almost all the drugs have an affinity towards their protein ligand. Rimantadine was found to be exhibiting highest interaction with least energy. Furthermore, this study identified pocket identification of the receptors and the ligand binding site.

Keywords :

Epidemics, Interaction, Least energy and Pocket identification